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MISTR is for HIV-negative adults (18+) who are looking to protect themselves from HIV and prefer to receive judgement free treatment from the convenience and privacy of their own home. We can also help you if you have been exposed to HIV in the last 24-hours and need to start PEP.

Using MISTR is fast, easy and secure. The initial health questionnaire takes 5-10 minutes to complete, and you can receive your first bottle of Truvada in 5 to 7 business days, depending on how quickly you get your required labs completed.  The required lab testing can be done home. GET STARTED NOW

Yes. PrEP prescribed via MISTR is prescribed using the same rules and medical standards as any other physician. A MISTR medical professional will only prescribe a medication if it is safe to do so based your lab results and the information provided by you in the health questionnaire.

Yes.  Your information is transmitted to us using industry standard encryption and stored in an encrypted form on our servers according to strict federal standards, including HIPAA. You can read our Privacy Policy for more details.

Yes.  Before you can start PrEP, you will need to complete health questionnaire and the required lab work, which will test for HIV, Hepatitis B and your Kidney Function.  Once complete, a doctor will review results and, if appropriate, write you a prescription for PrEP.

Once you completed your health questionnaire and your lab results have been received and reviewed by one of our licensed physicians, your prescription will be sent to one of our partner pharmacies.  Your prescription will then ship within 48-hours, and typically arrive anywhere between 1-2 business days. You will be able to track the status of your order via your MISTR PROFILE and the tracking code is sent via email.

Yes.  Once we’ve collected your basic details, you will be asked if you already have a prescription. If you do, we can process and ship your prescription the same day before 3pm PT.  We offer free delivery and will work on your behalf to ensure you have little or no out of pocket expenses.

Yes.  After you complete your health questionnaire you can consult with a physician via your MISTR PROFILE using secure online chat, phone call or a video chat.

It depends. Certain states require a video chat with your doctor. After your initial onboarding, a physician will reach out with the appropriate next steps.

Once you complete the online health questionnaire, our at home test kit will be automatically sent to you. Simply collect all of your samples, mail it back to us, and we’ll have your test results in just a few days!  All kits come with self-addressed with pre-paid Priority Mail postage, so just throw it in the mailbox whenever you’re ready.

New York has legislation that doesn’t allow us to offer at home testing kits. If you live in New York State we are only able to offer in-person testing.  You can make and modify appointments online via your MISTR PROFILE.

Lab results are normally received within two business days, after the lab has received your samples.  We’ll send you an email notifying you when you can view these results securely through your MISTR PROFILE.

No, but it is highly recommended as it typically delivers the fastest results, and can be done from the comfort of your home.  If you choose in-person testing, there are 2,200 locations across the U.S. you can choose from. Appointments can be made and modified online via your MISTR PROFILE.

It should take 15 minutes or less for in-person lab appointments. You can choose from 2,200 locations across the U.S. and you make and modify appointments online via your MISTR PROFILE.

Your PrEP will be delivered via USPS Priority Shipping or UPS Ground. The packaging is discreet and has no logos or mentions of MISTR, the pharmacy, or the contents inside.

Yes. MISTR will send you a tracking number via email each time you are sent an at home testing kit or prescription. You can also track your packages via your MISTR PROFILE.

MISTR’s at home testing kits allow you to perform the required labs yourself, with a simple finger-prick.  There are detailed instructions in your kit, but if you prefer, you can watch Uncle Billy break it down for you in our INSTRUCTIONAL VIDEO.


  1. Write your date of birth (DOB) on each blood card.
  2. Use an alcohol pad to clean the finger before pricking it.
  3. Let your blood drip onto the blood card, and be sure to fill each circle completely.
  4. Let the blood card dry for 10 minutes before closing it and putting it in the bag

MISTR’s at home STI testing kits allow you to perform the required labs for PrEP and test yourself for sexually transmitted infections (STIs) such as gonorrhea, chlamydia and syphilis. The kit requires a simple urine sample, swab samples and a finger-prick blood test, which should all take 10 minutes or less to complete.  There are detailed instructions in your kit, but if you prefer you can watch Uncle Billy break it down for you in our INSTRUCTIONAL VIDEO.


  1. Don’t throw out the liquid in each tube.
  2. Fill the urine tube anyplace in between the two lines.
  3. The oral swab should be used for 20-30 seconds, in the back of the throat
  4. The anal swab should go in about 2 inches and be rotated for 20-30 seconds.

NOTE: If you have tested positive for syphilis previously, you will not be able to utilize our at home test to detect a new syphilis infection.

If you test positive for HIV or other sexually transmitted disease your assigned doctor will reach out to you directly with treatment options. 

Yes, but if you choose the MISTR Pharmacy Network, we will handle all the required paperwork to ensure you have little or no out-of-pocket costs, and we’ll ship your medication in our discreet packaging for free.  We also offer customer support 365 days a year. 

If you want, we can send your prescription to another pharmacy of your choosing in the Surescripts Network, but then you will have to pick up your prescription in person and handle any additional paperwork on your own.

MISTR does not share your information with anyone without your permission. MISTR is private and confidential just like all healthcare services. You can read our Privacy Policy for further details.

MISTR can be accessed 24-hours a day, 7-days a week.  You can call or message us at any time, but all messages and phone calls will be responded to Monday – Friday, 10am to 8pm Eastern Time.

Billing & Insurance

Yes, we accept all insurance. The online doctor consultation and required labs together are covered, and we utilize your insurance to cover the cost of your prescription. If you are uninsured or under-insured we will work on your behalf to enroll you in one of various patient assistance programs, to ensure you have no out of pocket expenses. We manage the entire process for you.

The online doctor consultation and required labs are free as a resident of California. If you are uninsured or under-insured we will work on your behalf to enroll you in one of various patient assistance programs, to ensure you have no out of pocket expenses. We manage the entire process for you.

Yes, we do. If for any reason your PrEP medication is not covered, we will get you in enrolled in one of the various patient assistance programs, to ensure that you will have no out of pocket expenses. We manage the entire process for you. For residents of California, the online doctor consultation and required labs are free.

The online doctor consultation and required labs are free.

In the state of California the required labs and doctor consultation are free, so there’s no need to bill insurance.

PrEP is covered by most insurance companies, Medicaid and Medicare. If you don’t have insurance or have been denied coverage for your PrEP medication, we will get you in enrolled in one of the various patient assistance programs to cover the cost of your medication. We manage the entire process for you.

No problem.  We can get your PrEP medication covered if you are on your parent’s/guardian’s or spouse’s insurance plan.

MISTR won’t tell your parent(s) or anyone else that you are on Truvada® for PrEP.  As part of regular health insurance communications, your insurance company may send some of your confidential health information—like the services you received and when—to the policyholder of your health plan.

Yes. All payments are processed through industry standard credit card systems.

The transaction will show MISTR and the amount. No other details will appear.

For questions or concerns about overdraft fees, please contact your bank directly.

Telehealth and TelePrEP

MISTR provides a new way for you to communicate with a doctor, but we do not replace them. When you make a request through our platform, the request is sent to a doctor licensed in your state who will provide you the best possible care from the convenience of your home or office.

To prescribe medicine, a physician must be licensed in the state where the patient is located.   MISTR is only available in the states where physicians on the MISTR platform are licensed, but we are expanding quickly. GET STARTED NOW to see if we are available in your state.

Our medical team is comprised of independent doctors (MD), nurse practitioners (NP), physician assistants (PA), and registered nurses (RN) licensed in your state.  Each of our physicians undergo an extensive background check and license verification process.

Yes. MISTR has built its’ telemedicine platform to enable physicians to practice medicine and take care of patients remotely. Every doctor you interact with is board certified and licensed to prescribe medicine, treat patients in your state, and complies with all U.S. medical laws.  If you have feedback about the platform or a complaint regarding a physician on the MISTR platform, please email [email protected].

Yes. Telemedicine is safe and effective—as long as patients answer questions truthfully, accurately, and completely. Doctors are only effective when they have accurate, current information about your case—both in telemedicine and in-person visits.

MISTR is not intended to replace your primary care physician. It’s important to keep your primary care physician and any other physicians involved in your care up to date with the care you receive from MISTR. You can go to your MISTR PROFILE at any time and message the medical support team if you would like to share your medical information with your primary care physician or another doctor.

It is a good idea for your primary care physician to have a full picture of your health, and we encourage you to share the health information we have about you with your primary care physician. You’re in control though, so we will not send them anything without your express permission. You can go to your MISTR PROFILE at any time and message the medical support team if you would like to share your medical information with your primary care physician or another doctor.

What is PrEP?

PrEP (Pre-exposure Prophylaxis) is a once-daily pill for people who are HIV-negative. PrEP helps to prevent individuals from contracting the HIV virus, should the individual be at risk of exposure or come into contact with the virus. Currently, the only FDA approved and available medication for PrEP is Truvada®, which was approved for HIV prevention in 2012 and contains two medications: tenofovir and emtricitabine. Studies have shown that PrEP is 99% effective at preventing HIV when taken daily as prescribed.

When taken daily as directed, PrEP is 99% effective in preventing HIV-negative people from contracting the HIV virus. Learn more about the Centers for Disease Control (CDC) review of the clinical trials and studies here.

PrEP takes about 7 days before it is fully effective in rectal tissue. However, the CDC recommends taking PrEP every day for 21 days prior to any possible exposure to HIV. The drug must be potent enough in the bloodstream to block HIV infection. Taking a pill right before or immediately after possible exposure to the virus will not protect against a potential HIV infection.

PrEP does not prevent any other sexually transmitted diseases (STDs) or sexually transmitted infections (STIs) other than HIV. It is important to be tested regularly for other sexually transmitted diseases and infections.

PrEP (a.k.a. Truvada) is a once daily pill that works by blocking an enzyme called HIV reverse transcriptase. By blocking this enzyme, HIV is prevented from replicating itself inside the body.

Truvada® is the brand name of the drug, PrEP. It is a single pill that you take every day, and it is the only drug approved for PrEP by the U.S. Food and Drug Administration (FDA). Truvada® combines two medicines in one: emtricitabine and tenofovir.

You may have heard about other forms of PrEP (e.g. shot, other pills), but all of these are still in clinical trials and not approved by the FDA.

There are no generic versions of Truvada® for PrEP available in the United States.

PrEP is most effective when taken every single day. If you take PrEP daily, the level of protection is about 99%. If you take PrEP four times per week, the level of protection is about 96%. When taken less than 4 days per week, the potency of the drug in the bloodstream is greatly reduced, and the drug’s effectiveness drops dramatically. If you miss a dose, make sure to take the next one, but there is no need to double up.

For the most part, yes, but it is important that you list any drugs you are currently taking when completing the health questionnaire.

There are no known interactions with alcohol and/or recreational drugs and Truvada®, the FDA approved medication for PrEP.

No, you do not need to take this medication with food.

Those taking PrEP report little to no side effects, but symptoms such as headache, abdominal pain, and weight loss can happen. These side effects typically do not last long and often go away entirely within the first month. If you’re experiencing prolonged side effects, please let your doctor know, who you can message directly from your MISTR PROFILE.

No. PrEP is preventative, and should NOT to be taken after you are exposed to HIV. If exposed to HIV in the last 72-hours, you can take PEP, also known as post-exposure prophylaxis.

Pre-exposure prophylaxis is PrEP, a way to prevent HIV infection by taking the pill Truvada® every day. The word “prophylaxis” means “to prevent or control the spread of an infection or disease” Pre (before), Exposure (coming into contact with HIV), Prophylaxis (treatment to
prevent an infection from happening).

PrEP only needs to be taken while at risk of exposure to HIV. As sexual habits change, PrEP may not need to be continued. This is something you can discuss with a doctor via your MISTR PROFILE. When deciding to stop PrEP, you should continue to take it daily for at least four weeks after the last possible risk of exposure to HIV.

What is PEP?

Post-exposure prophylaxis (PEP) is a month-long (28 day) course of anti-HIV medications that must be started within 72-hours of possible exposure to HIV to prevent permanent infection.
PEP’s effectiveness varies depending on when it is initiated. According to the CDC it can be up to 80% effective. You can learn more about PEP here.

PEP consists of 2-3 antiretroviral medications, the same medicines that people with HIV take to stay healthy. If exposed to HIV, it takes a few days for an HIV infection to take hold in the body. After starting PEP, the medication stops the virus from multiplying. As you continue taking PEP for the full 28–days, cells that have been infected with HIV die. The virus will then not spread to the rest of the body.

PrEP is a preventative medication that you take proactively each day to prevent HIV. PrEP stands for pre-exposure prophylaxis. PEP is the medication you take to prevent HIV after you have been exposed to the virus. PEP is a month-long (28 day) course of anti-HIV medications
that must be started within 72-hours of exposure. PEP stands for post-exposure prophylaxis.